Physis™ – Naturally Sourced Tissue, Cryopreserved For Optimal Results
Discover how Physis™ can be integrated in your surgical procedure using natural tissue from the umbilical cord — safely and ethically sourced.
What Is Physis™?
Physis™ is a safe, natural human tissue allograft derived from the umbilical cord. Application is during a variety of surgical procedures to supplement or replace damaged or lost tissue.
This tissue, called Wharton’s Jelly, is an extracellular matrix (ECM) scaffold that comes cryofrozen, preserving essential elements in native human placental tissue.
Common Questions
- Is it safe?
Yes. Physis™ is processed under strict safety standards and regulated by the FDA (section 361 of the Public Health Service Act). - Where does it come from?
It’s derived from healthy umbilical cords donated by consenting mothers after full-term, planned C-section deliveries. - What should I expect from Physis™?
Physis™ can be used during a surgical procedure to help support your recovery. It may be implanted to replace lost or damaged tissue, depending on your procedure.
Your doctor will let you know how Physis™ fits into your healing journey.
For Healthcare Professionals
Physis Graft™ Allograft
Physis Graft allografts are processed from donated human umbilical cords to preserve the natural characteristics and structural integrity of Wharton’s Jelly (WJ). Staying within the primary purpose of WJ in the umbilical cord, Physis allograft’s homologous use stays consistent when there is a need to implant human allograft to fill, seal, or replace lost/damaged tissue. WJ’s connective tissue preserves the natural integrity of the human body and provides essential components in tissue regeneration. 1,2,3,4
• The WJ is a mucoid connective matrix with high durability and pliability1
• Wharton’s jelly is abundant in extracellular matrix, composed of :
- Glycosaminoglycans (GAG’s) • Hyaluronic acid
- Hyaluronan Complexes • Heavy Chain 1 of inter alpha inhibitor
- Platelet-derived growth factor (PDGF)
- FGF
- IGF-I
- Microvesicles (MVs) • Collagen types I, III, and V • Cytokines1,2
1 Velarde F, Castañeda V, Morales E, Ortega M, Ocaña E, Álvarez-Barreto J, Grunauer M, Eguiguren L and Caicedo A (2020) Use of Human Umbilical Cord and Its Byproducts in Tissue Regeneration. Front. Bioeng. Biotechnol. 8:117. doi: 10.3389/fbioe.2020.00117 2Sobolewski K, Bańkowski E, Chyczewski L, Jaworski S. Collagen and glycosaminoglycans of Wharton’s jelly. Biol Neonate. 1997;71(1):11-21. doi: 10.1159/000244392. PMID: 8996653. 3Gupta A, El-Amin SF 3rd, Levy HJ, Sze-Tu R, Ibim SE, Maffulli N. Umbilical cord-derived Wharton’s jelly for regenerative medicine applications. J Orthop Surg Res. 2020 Feb 13;15(1):49. doi: 10.1186/s13018-020-1553-7. PMID: 32054483; PMCID: PMC7017504.
Ordering Information
Telephone: 602-920-0197
E-mail: orders@deitus.net
Address: Deitus LLC, PO Box 5317, Scottsdale, AZ 85261
Deitus WJ allografts are regulated under section 361 of the Public Health Service Act (PHS) and 21 CFR Part 1271. Physis is processed to preserve the structural integrity and original relevant characteristics of Wharton’s jelly as observed in the donor and is intended for homologous use only. Deitus’birth tissue allografts are derived from healthy, consenting mothers after full-term, live, planned, Cesarean section (C-section) deliveries.
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